Research Studies: Depression

DBSA does not endorse nor recommend any particular research study. Patients should discuss all options with their health care providers and family members before beginning any study.

Many people think that participating in a research study means they will get better treatment for their illness. While this may be true, it's important to remember that a research study is conducted for research purposes—it does not ensure better or safer treatment.

Taking part in a study does not guarantee individual benefits to the participant in the form of newer or safer treatment. The contribution made participating in a research study is to science first and to the patient second.

DBSA, its advisors, and its consultants do not endorse or recommend the use of any specific treatment or medication. For advice about specific treatment or medication, patients should consult their physicians and/or mental health professionals.


PET Imaging of mGluR5 with Drug Challenge (New Haven, CT)

We are looking for people who have major depressive disorder to participation in a brain-imaging study to examine certain receptors in the brain that may be related to depression, and the effect of a drug called ketamine on those receptors.

To be eligible you must:
-Be between the ages of 18-65
-Have a diagnosis of major depressive disorder (MDD)
-Be currently depressed
-Not use drugs or drink a lot of alcohol

If you choose to participate, you will have 2 fMRI and 3 PET scans, and receive an administration of ketamine. You will be paid up to $990. Study participation duration is 1–2 months

Contact:
Nicole DellaGioia
Phone: (203) 737-6884
Email:nicole.dellagioia@yale.edu

Deadline for Enrollment: March 2016


Depression treatment options: What matters most?

We are conducting a national survey to better understand what is important to patients and clinicians when making decisions about treatments for depression. Responses to this survey are anonymous and confidential. For more information or to take the survey, please follow the appropriate link below.

If you have had depression: http://tinyurl.com/patient-treatment-survey

If you are a clinician who treats people with depression: http://tinyurl.com/clinician-treatment-survey

Contact:
Rachel Forcino
Phone: 603-646-8736
Email: rachel.forcino@dartmouth.edu

Deadline for Enrollment: 11/30/2014


MDD Study for Treatment-Resistant Depression (Skokie, IL)

If you have failed 1-2 antidepressants or would like to boost the effectiveness of your current antidepressant, consider participating in this study!

Psychiatric Medicine Associates, LLC, in Skokie is conducting an 8-week study regarding the treatment of major depressive disorder using the study drug in conjunction with an FDA-approved antidepressant. Participants will receive study-related laboratory assessments and physical examinations at some visits at no cost. Health insurance is not required!

Upon study conclusion, study completers may be eligible to receive up to 90 days of free treatment. All medical records can be shared with your current healthcare provider.

If you are between the ages of 18-70, are in good health, and have no dependency on illicit drugs and/or alcohol, this study may be a great treatment option for you!

Contact:
Rae Watkins, PsyD
Phone: (847) 679-8000
Email: rae_watkins@rush.edu

Deadline for Enrollment: January 5, 2016


Potential Use of Brain Network Activation (BNA) Analysis Using Evoked Response Potentials to Diagnose Unipolar Major Depression and Bipolar I Depression and Assess Response to Treatment (Skokie, IL)

Help researchers find the biological indicator of depression and bipolar disorder by participating in the Brain Network Activation study (i.e., EEG)!  If you are currently battling depression or bipolar disorder, you may qualify to participate in the study.

This study lasts 6-8 weeks and involves a non-invasive treatment. If you aren't currently receiving medication, you will receive one that is already FDA-approved. The study consists of approximately three visits with an EEG conducted at each. Upon the end of the study, study completers may be eligible for up to 90 days of free treatment.

Participants must be between the ages of 18-55, have normal (corrected) vision, normal hearing and be in good health.

Contact:
Rae Watkins, PsyD
Phone: (847) 679-8000
Email: rae_watkins@rush.edu
www.elminda.com

Deadline for Enrollment: January 5, 2016


Major Depressive Disorder Study for Females Only (Skokie, IL)

If you have failed to successfully treat your depression, this study may be a great treatment option for you!

We are conducting a 24-week study for women between the ages of 18-65, who meet the criteria for Major Depressive Disorder and who have previously failed to respond to adequate trials of one or two antidepressant treatments (ADTs). The study is investigating a cutting-edge compound for the treatment of Major Depressive Disorder, which is already FDA approved for indications outside of depression.  Consider participating if you are a female and would like to explore treatment options beyond ADTs that have not adequately addressed your symptoms.

No other psychiatric medications (i.e., mood medication) will be permitted during study participation.  If needed, study doctors will assist patients in tapering off their current medication prior to starting the study.

Subjects who are randomized have a 50/50 chance of receiving placebo.

Contact:
Rae Watkins, PsyD
Phone: (847) 679-8000
Email: rae_watkins@rush.edu

Deadline for Enrollment: January 5, 2015


A Phase 3, Double-Blind, Placebo-Controlled study of Cariprazine as adjunctive therapy in Major Depressive Disorder (Skokie, IL)

18-19 week augmentation study for adults who are 18-65 years of age, meet the criteria for Major Depressive Disorder and have failed to respond to adequate trials of one or two antidepressants, in the past. Patients who meet criteria for the study will enter into a an 8 week open-label anti-depressive phase, followed by 8 week double blind treatment period. All subject will remain on their background antidepressant medication throughout the study.

There is an 8 week double-blind treatment period, where there is a 50/50 chance of receiving active medication or placebo.

Contact:
Rae K. Watkins, PsyD
Phone: 847-679-8000
Email: rae_watkins@rush.edu

Deadline for Enrollment: 2015


Predictors of Treatment Outcome with CBT (New York, NY)

Looking for psychotherapy for depression?

If you are depressed and between age 18-65, you may be eligible for a research study offering psychotherapy at NO COST to you at The New York State Psychiatric Institute/Columbia University. We will provide twelve weeks of cognitive-behavioral therapy for Major Depressive Disorder at NO COST to you as part of a brain imaging study. Your participation can help further our understanding of depression and speed the recovery of others who suffer from depression in the future. You will be compensated up to $250 for your time and effort if you are eligible and choose to participate. For more information, please call Lauren at (212) 543-6240.

Contact:
Lauren
Phone: (212) 543-6240
Email: delapar@nyspi.columbia.edu

Deadline for Enrollment: November 30, 2014


Depression Research Study (Ann Arbor)

The purpose of this study is to examine the relationship between emotion and memory. The goal of this study is to try to understand how the brain processes information in those with Major Depressive Disorder by understanding how interference is resolved in perceptual, memory, and motor processes. This, in turn, may help us understand ruminative processes among depressed individuals.

In this study, participants will first be asked to undergo a clinical diagnostic interview with a trained clinician, graduate student, post docs, or other trained personnel who have undergone formal training in administering the interview. During that time we will ask you questions about your emotional and physical well-being. This interview, which will last approximately 1-2 hours, will help determine if participants are eligible to continue in the study. This session pays $20.00 an hour.

If eligible, participants will be invited back to participate in various studies, which include performing computer-based tasks. Participants will also be asked to complete several questionnaires pertaining to their moods and emotions. This session pays $20.00 an hour as well.

Contact:
Catherine
Phone: 734-647-6249
Email: jlabfbstudy@umich.edu

Deadline for Enrollment: OPEN


Mothers with Depression Needed

Are you a mother with a daughter who is 9-14 years old? Have you had episodes of depression during your daughter's lifetime?

If so, you may be eligible to participate in a study of how moms and their daughters think and process emotional information.

The study takes place in the Psychology Department at Stanford University. You and your daughter would participate in interviews, fill out questionnaires, do computer tasks, have discussions with each other, and possibly be eligible for a brain scan. Involvement in the study requires a time-commitment of 3-10 hours over the course of one to three visits. We will schedule the sessions around your availability (daytime, evenings, or weekends are all fine).

Eligible pairs receive $40/hour for their time.

To be eligible for this study:

  • you must have a daughter between the ages of 9 and 14
  • you must have had episodes of depression during your daughter's lifetime
  • you must be a US citizen or hold a Green Card
  • you must read and speak English fluently
  • you should have no immediate plans to leave the Bay Area

If you would like to receive more information about this study, please email mood@psych.stanford.edu or call (650) 723-0804 to reach the study coordinator, Hannah Burley. Please refer to study #101. For general information about participant rights, contact 1-866-680-2906.

Your performance in all study-related activities, including requests for information will be kept completely confidential.

Deadline for enrollment: OPEN


Mother-Daughter Depression Study

Are you a mother with a daughter who is 10-14 years old? Have you had episodes of depression during adulthood?

If so, you may be eligible to participate in a study of how moms and their children think and process emotional information. The study takes place in the Psychology Department at Stanford University. You and your daughter would participate in interviews, fill out questionnaires, and have a scan taken of your daughter's brain.

Eligible mother-child pairs will receive $40/hour for their time. The study would last from 2-6 hours over the course of two or three visits. We will schedule the sessions around your availability (daytime, evenings, or weekends are all fine).

To be eligible for this study:

  • you must have a daughter between the ages of 10-14
  • you must be a US citizen or non-citizen with a Green Card
  • you must read and speak English
  • you should have no immediate plans to leave the Bay Area

Contact:
If you would like to receive more information about this study, please email mood@psych.stanford.edu or call (650) 723-0804 to reach the study coordinator, Hannah Burley. Please refer to study #3272. For general information about participant rights, contact 1-866-680-2906.

http://mood.stanford.edu/

Deadline for Enrollment: 2015


Sleep and Memory

Sleep and Memory Study

  • Depressed participants needed
  • Males and females over the age of 18
  • No history of head injury causing unconsciousness
  • Able to spend 2 to 4 nights in the lab and keep a fixed sleep schedule
  • Willing to complete interview, questionnaires, and computer tasks
  • Monetary compensation of $75 per lab night

Contact:
Adrienne McHenry
248-719-3887
amchenry@umich.edu


Depression Research Study

Feeling overwhelmed? sad? depressed? You may be suffering from depression.
Doctors at the University of California Los Angeles are researching a new technology to predict antidepressant effectiveness. Qualifying participants, ages 18-75, will receive antidepressants, study-related exams, tests and clinical consultations - at no cost. Also, monetary compensation may be provided. We conduct numerous studies on depression and enrollment is ongoing.

Contact:
Lab of Brain, Behavior, and Pharmacology
310-825-3351
rohitm@brain.ucla.edu
http://www.brain.ucla.edu/

Deadline: Open


Depression Research Study (Southern California)

A Placebo-Controlled, Add-On (“Natural Supplement”) Study of MSI-195 (S-Adenosyl-L-Methionine, SAMe) For Patients With Major Depressive Disorder (MDD) Who Have Had An Inadequate Response to Current Antidepressant Therapy

The purpose of this study is to evaluate the safety and effectiveness of MSI-195 (SAMe) as an add-on treatment to an ongoing antidepressant medication. Qualified participants must be between 21 and 70 years of age and diagnosed with Depression. The duration of study participation is approximately two-to-three months, with up to six clinic visits and three telephone visits. Study-related care is provided at no cost to participants and compensation for travel is available. 

Pharmacology Research Institute (PRI) has been conducting research studies since 1975. Our offices are located in Orange County, Long Beach/Los Alamitos and Encino/San Fernando Valley. Please feel free to contact us or visit our website for more information. 

Contact:             
Mellissa M. Henry, R.N., M.S.N., N.P.
(888) 774-4673 or (714) 827-3667
mhenry@priresearch.com
www.priresearch.com

Deadline: Open


Deep brain stimulation for TRD

This study, conducted by Dr. Helen Mayberg, is looking a deep brain stimulation for the treatment of patients with treatment resistant depression. We are currently recruiting patients with bipolar type II depression and unipolar depression. For more information please contact us or visit our clinical trials website at: http://clinicaltrials.gov/ct2/show/NCT00367003?term=deep+brain+stimulation+for+depression&rank=6

Contact:
Megan Filkowski
dbs@emory.edu
(404)727-9228
http://clinicaltrials.gov

Deadline: Open