Research Studies: Depression
DBSA does not endorse nor recommend any particular research study. Patients should discuss all options with their health care providers and family members before beginning any study.
Many people think that participating in a research study means they will get better treatment for their illness. While this may be true, it's important to remember that a research study is conducted for research purposes—it does not ensure better or safer treatment.
Taking part in a study does not guarantee individual benefits to the participant in the form of newer or safer treatment. The contribution made participating in a research study is to science first and to the patient second.
Major Depressive Disorder - Augmentation (Chicago & Skokie, IL)
Depressed? Need treatment real treatment?
We are conducting an augmentation therapy study that provides treatment for individuals currently experiencing symptoms of Major Depressive Disorder. Participants will be assigned one of two currently approved antidepressants as a background therapy. Subjects will also be given study medication (augmentation therapy), in conjunction with their assigned background product. The augmentation therapy is a currently approved medication that is being studied for dose-ranging efficacy and safety of use in combination with an antidepressant.
Subjects must be between 18-65 years of age.
There are 15 office visits over 18-21 weeks ($50 per visit paid). All labs and physical exams are conducted at no charge for participants.
ALL subject will receive treatment with an approved antidepressant! Open to participants that have never taken an antidepressant for their depression and those who are currently being treated with an antidepressant and still experiencing symptoms of depression or have failed an antidepressant in the past.
Deadline for Enrollment: 1/5/2015
Treatment Resistant MDD Infusion Study (Skokie, IL)
The purpose of this study is to assess the effect and safety of AZD6765 in patients with major depressive disorder who exhibit inadequate response to antidepressants. AZD6765 is a channel blocker of the NMDA class of glutamate receptors.
AZD6765 is similar to approved drugs called memantine and ketamine. Memantine is used for treatment of moderate-to-severe dementia of Alzheimer's type. Ketamine is used as a general anesthetic (a substance that causes lack of feeling or awareness; a general anesthetic puts the person to sleep). Studies of ketamine have suggested that low doses of this type of drug may help in treating depression.
Patients may continue to take their current antidepressant medication while enrolled in the study.
Excluded Medication: MAOIs, Depakote, carbamazepine, lamotrigine, topiramate, opiates, memantine, barbiturates, or bupropion >300mg/day.
ECT, VNS, TMS in past 6 months or DBS ever. The randomized double-blind dosing period will last up to 12 weeks. Subjects will receive either 50 mg or 100 mg of IV AZD6765 or placebo. There is a 1/3 chance of a participant receiving no-treatment.
Deadline for Enrollment: 1/30/2014
Novel Mechanisms Underlying Depression (New York, NY)
Are you depressed?
If you are depressed and between ages 21-55, you may be eligible for a brain imaging research study at The New York State Psychiatric Institute/Columbia University. We will provide six months of treatment visits with an experienced psychiatrist as part of participation; inpatient treatment is also available. This study involves a thorough psychiatric and medical evaluation, an MRI, a PET scan, and six months of treatment. You may be compensated up to $450 for your time and effort of participating in this study. For more information, please call Lauren at (212) 543-6240 or email depressionstudy@ columbia.edu. You can also visit our website at https://sites.google.com/site/columbiadepressionstudy/
Individuals currently taking antidepressants will only be enrolled if their medications are ineffective; such subjects would undergo medication taper over one week followed by a three-week washout prior to imaging and subsequent treatment.
More information can be found on the trial website: www.tinyurl.com/depressionstudy
Deadline for Enrollment: 7/21/2014
Predictors of Treatment Outcome with CBT (New York, NY)
Looking for psychotherapy for depression?
If you are depressed and between age 18-65, you may be eligible for a research study offering psychotherapy at NO COST to you at The New York State Psychiatric Institute/Columbia University. We will provide twelve weeks of cognitive-behavioral therapy for Major Depressive Disorder at NO COST to you as part of a brain imaging study. Your participation can help further our understanding of depression and speed the recovery of others who suffer from depression in the future. You will be compensated up to $250 for your time and effort if you are eligible and choose to participate. For more information, please call Lauren at (212) 543-6240.
Deadline for Enrollment: November 30, 2014
CSUF Family Lab: Feelings in the Family Study (Fullerton, CA)
Researchers are interested in better understanding how family members get along when a parent is experiencing depressive feelings. This study specifically looks at mothers' depressive feelings. Participation involves a 30 to 40 minute phone interview and questionnaires by mail. In order to be included in the study, a potential participant must express that she is experiencing depressive feelings, and she must have at least one child between the ages of 6-12. Participating mothers will be asked about their depressive feelings, family relationships, and their child/children.
Participants will be compensated $25 for their time.
Deadline for Enrollment: 05/01/2013
Decision-Making in Depression and PTSD (Atlanta, GA)
The Emory Moood and Anxiety Disorders Program is conducting a study of how people with Major Depressive Disorder or Post-Traumatic Stress Disorder make decisions.
To Participate, you must be:
Participants will undergo a psychiatric assessment, questionnaires and tests about decision-making. The study will require 1 visit and a total of about 2-3 hours to complete.
Deadline for Enrollment: May 2013
Depression Research Study (Ann Arbor)
The purpose of this study is to examine the relationship between emotion and memory. The goal of this study is to try to understand how the brain processes information in those with Major Depressive Disorder by understanding how interference is resolved in perceptual, memory, and motor processes. This, in turn, may help us understand ruminative processes among depressed individuals.
In this study, participants will first be asked to undergo a clinical diagnostic interview with a trained clinician, graduate student, post docs, or other trained personnel who have undergone formal training in administering the interview. During that time we will ask you questions about your emotional and physical well-being. This interview, which will last approximately 1-2 hours, will help determine if participants are eligible to continue in the study. This session pays $20.00 an hour.
If eligible, participants will be invited back to participate in various studies, which include performing computer-based tasks. Participants will also be asked to complete several questionnaires pertaining to their moods and emotions. This session pays $20.00 an hour as well.
Deadline for Enrollment: OPEN
Mothers with Depression Needed
Are you a mother with a daughter who is 9-14 years old? Have you had episodes of depression during your daughter's lifetime?
If so, you may be eligible to participate in a study of how moms and their daughters think and process emotional information.
The study takes place in the Psychology Department at Stanford University. You and your daughter would participate in interviews, fill out questionnaires, do computer tasks, have discussions with each other, and possibly be eligible for a brain scan. Involvement in the study requires a time-commitment of 3-10 hours over the course of one to three visits. We will schedule the sessions around your availability (daytime, evenings, or weekends are all fine).
Eligible pairs receive $40/hour for their time.
To be eligible for this study:
If you would like to receive more information about this study, please email email@example.com or call (650) 723-0804 to reach the study coordinator, Hannah Burley. Please refer to study #101. For general information about participant rights, contact 1-866-680-2906.
Your performance in all study-related activities, including requests for information will be kept completely confidential.
Deadline for enrollment: OPEN
Mother-Daughter Depression Study
Are you a mother with a daughter who is 10-14 years old? Have you had episodes of depression during adulthood?
If so, you may be eligible to participate in a study of how moms and their children think and process emotional information. The study takes place in the Psychology Department at Stanford University. You and your daughter would participate in interviews, fill out questionnaires, and have a scan taken of your daughter's brain.
Eligible mother-child pairs will receive $40/hour for their time. The study would last from 2-6 hours over the course of two or three visits. We will schedule the sessions around your availability (daytime, evenings, or weekends are all fine).
To be eligible for this study:
Deadline for Enrollment: 2015
Sleep and Memory
Sleep and Memory Study
Major Depression & Type 2 Diabetes
The purpose of the study is to examine the relationship between brain structure and depression in adults aged 30 or older with Diabetes. This relationship is determined using MRI technology.
Deadline: June 2014
Depression Research Study
Feeling overwhelmed? sad? depressed? You may be suffering from depression.
Depression Research Study California
Pharmacology Research Institute is seeking volunteers for a clinical research study to evaluate the safety and effectiveness of an investigational medication for the treatment of depression. To qualify for participation you must be at least 18 years old, be experiencing symptoms of depression, be within driving distance of Encino, Long Beach/Los Alamitos or Newport Beach
As a qualified participant you will receive, at no cost: monitoring of depression symptoms, study-related examinations, study-related medication. If you are experiencing depression please call 888-PRI-HOPE [774-4673] or visit our website at http://www.priresearch.com/ to learn more about becoming a participant in this important research study.
Deep brain stimulation for TRD
This study, conducted by Dr. Helen Mayberg, is looking a deep brain stimulation for the treatment of patients with treatment resistant depression. We are currently recruiting patients with bipolar type II depression and unipolar depression. For more information please contact us or visit our clinical trials website at: http://clinicaltrials.gov/ct2/show/NCT00367003?term=deep+brain+stimulation+for+depression&rank=6
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