Research Studies: Depression

DBSA does not endorse nor recommend any particular research study. Patients should discuss all options with their health care providers and family members before beginning any study.

Many people think that participating in a research study means they will get better treatment for their illness. While this may be true, it's important to remember that a research study is conducted for research purposes—it does not ensure better or safer treatment.

Taking part in a study does not guarantee individual benefits to the participant in the form of newer or safer treatment. The contribution made participating in a research study is to science first and to the patient second.

DBSA, its advisors, and its consultants do not endorse or recommend the use of any specific treatment or medication. For advice about specific treatment or medication, patients should consult their physicians and/or mental health professionals.


A Phase 3, Double-Blind, Placebo-Controlled study of Cariprazine as adjunctive therapy in Major Depressive Disorder (Skokie, IL)

18-19 week augmentation study for adults who are 18-65 years of age, meet the criteria for Major Depressive Disorder and have failed to respond to adequate trials of one or two antidepressants, in the past. Patients who meet criteria for the study will enter into a an 8 week open-label anti-depressive phase, followed by 8 week double blind treatment period. All subject will remain on their background antidepressant medication throughout the study.

There is an 8 week double-blind treatment period, where there is a 50/50 chance of receiving active medication or placebo.

Contact:
Rae K. Watkins, PsyD
Phone: 847-679-8000
Email: rae_watkins@rush.edu

Deadline for Enrollment: 2015


Cognitive Factors Moderating the Effects of Rumination on Depressed Mood
(Thinking Styles and Mood Study)

Research has shown that peoples' thoughts and feelings are strongly connected. This study aims to learn more about how different styles or ways of thinking can affect peoples' moods, both positively and negatively. Participants will complete a brief (20 min.) online survey about their typical thinking patterns, mood, and current symptoms they may have. Responses to the survey are ANONYMOUS, simply follow the study link to participate. By studying the connection between thinking styles and mood, researchers can identify factors that put people at risk for developing mood disorders, such as depression. In addition, this research may aid in the development of effective treatments for these disorders.

This is an online study and does not require session attendance. Contacting the administrators is not necessary to participate:
http://www.surveymonkey.com/s/98RM2SG

Contact:
Joseph Smetter
Phone: 712-253-4858
Email: jsmetter@hawk.iit.edu

Deadline for Enrollment: July 2014


An Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (multiple locations)

This clinical research study will be a multicenter, randomized, double-blind, placebo-controlled, parallel-group, flexible dose, 18-19 week study in patients with Major Depressive Disorder as diagnosed per DSM.IV-TR (4th ed., text rev.; DSM–IV–TR; American Psychiatric Association, 2000) who have an inadequate response to Antidepressant therapy (ADT) in their current episode. The study will include 4 periods: a 1-2-week screening period, followed by an 8-week open-label ADT period, followed by an 8-week double-blind treatment period, followed by a 1-week safety follow-up period.

Website: www.mosaicmdd.com 

Deadline for Enrollment: May, 2014


Major Depressive Disorder - Augmentation (Chicago & Skokie, IL)

Depressed? Need treatment real treatment?

We are conducting an augmentation therapy study that provides treatment for individuals currently experiencing symptoms of Major Depressive Disorder. Participants will be assigned one of two currently approved antidepressants as a background therapy. Subjects will also be given study medication (augmentation therapy), in conjunction with their assigned background product. The augmentation therapy is a currently approved medication that is being studied for dose-ranging efficacy and safety of use in combination with an antidepressant.

Subjects must be between 18-65 years of age.

There are 15 office visits over 18-21 weeks ($50 per visit paid). All labs and physical exams are conducted at no charge for participants.

ALL subject will receive treatment with an approved antidepressant! Open to participants that have never taken an antidepressant for their depression and those who are currently being treated with an antidepressant and still experiencing symptoms of depression or have failed an antidepressant in the past.

All subjects will be treated with an antidepressant during the trial. Subjects who are randomized have a 1/5 chance of receiving a placebo of the augmentation study medication.

Contact:
Rae K. Watkins, Psy.D
Phone: 847-679-8000
Email: rae_watkins@rush.edu

Deadline for Enrollment: 1/5/2015


Novel Mechanisms Underlying Depression (New York, NY)

Are you depressed?

If you are depressed and between ages 21-55, you may be eligible for a brain imaging research study at The New York State Psychiatric Institute/Columbia University. We will provide six months of treatment visits with an experienced psychiatrist as part of participation; inpatient treatment is also available. This study involves a thorough psychiatric and medical evaluation, an MRI, a PET scan, and six months of treatment. You may be compensated up to $450 for your time and effort of participating in this study. For more information, please call Lauren at (212) 543-6240 or email depressionstudy@ columbia.edu. You can also visit our website at https://sites.google.com/site/columbiadepressionstudy/

Individuals currently taking antidepressants will only be enrolled if their medications are ineffective; such subjects would undergo medication taper over one week followed by a three-week washout prior to imaging and subsequent treatment.

More information can be found on the trial website: www.tinyurl.com/depressionstudy

Contact: Lauren
Phone: (212) 543-6240
Email: depression-study@columbia.edu

Deadline for Enrollment: 7/21/2014


Predictors of Treatment Outcome with CBT (New York, NY)

Looking for psychotherapy for depression?

If you are depressed and between age 18-65, you may be eligible for a research study offering psychotherapy at NO COST to you at The New York State Psychiatric Institute/Columbia University. We will provide twelve weeks of cognitive-behavioral therapy for Major Depressive Disorder at NO COST to you as part of a brain imaging study. Your participation can help further our understanding of depression and speed the recovery of others who suffer from depression in the future. You will be compensated up to $250 for your time and effort if you are eligible and choose to participate. For more information, please call Lauren at (212) 543-6240.

Contact:
Lauren
Phone: (212) 543-6240
Email: delapar@nyspi.columbia.edu

Deadline for Enrollment: November 30, 2014


Depression Research Study (Ann Arbor)

The purpose of this study is to examine the relationship between emotion and memory. The goal of this study is to try to understand how the brain processes information in those with Major Depressive Disorder by understanding how interference is resolved in perceptual, memory, and motor processes. This, in turn, may help us understand ruminative processes among depressed individuals.

In this study, participants will first be asked to undergo a clinical diagnostic interview with a trained clinician, graduate student, post docs, or other trained personnel who have undergone formal training in administering the interview. During that time we will ask you questions about your emotional and physical well-being. This interview, which will last approximately 1-2 hours, will help determine if participants are eligible to continue in the study. This session pays $20.00 an hour.

If eligible, participants will be invited back to participate in various studies, which include performing computer-based tasks. Participants will also be asked to complete several questionnaires pertaining to their moods and emotions. This session pays $20.00 an hour as well.

Contact:
Catherine
Phone: 734-647-6249
Email: jlabfbstudy@umich.edu

Deadline for Enrollment: OPEN


Mothers with Depression Needed

Are you a mother with a daughter who is 9-14 years old? Have you had episodes of depression during your daughter's lifetime?

If so, you may be eligible to participate in a study of how moms and their daughters think and process emotional information.

The study takes place in the Psychology Department at Stanford University. You and your daughter would participate in interviews, fill out questionnaires, do computer tasks, have discussions with each other, and possibly be eligible for a brain scan. Involvement in the study requires a time-commitment of 3-10 hours over the course of one to three visits. We will schedule the sessions around your availability (daytime, evenings, or weekends are all fine).

Eligible pairs receive $40/hour for their time.

To be eligible for this study:

  • you must have a daughter between the ages of 9 and 14
  • you must have had episodes of depression during your daughter's lifetime
  • you must be a US citizen or hold a Green Card
  • you must read and speak English fluently
  • you should have no immediate plans to leave the Bay Area

If you would like to receive more information about this study, please email mood@psych.stanford.edu or call (650) 723-0804 to reach the study coordinator, Hannah Burley. Please refer to study #101. For general information about participant rights, contact 1-866-680-2906.

Your performance in all study-related activities, including requests for information will be kept completely confidential.

Deadline for enrollment: OPEN


Mother-Daughter Depression Study

Are you a mother with a daughter who is 10-14 years old? Have you had episodes of depression during adulthood?

If so, you may be eligible to participate in a study of how moms and their children think and process emotional information. The study takes place in the Psychology Department at Stanford University. You and your daughter would participate in interviews, fill out questionnaires, and have a scan taken of your daughter's brain.

Eligible mother-child pairs will receive $40/hour for their time. The study would last from 2-6 hours over the course of two or three visits. We will schedule the sessions around your availability (daytime, evenings, or weekends are all fine).

To be eligible for this study:

  • you must have a daughter between the ages of 10-14
  • you must be a US citizen or non-citizen with a Green Card
  • you must read and speak English
  • you should have no immediate plans to leave the Bay Area

Contact:
If you would like to receive more information about this study, please email mood@psych.stanford.edu or call (650) 723-0804 to reach the study coordinator, Hannah Burley. Please refer to study #3272. For general information about participant rights, contact 1-866-680-2906.

http://mood.stanford.edu/

Deadline for Enrollment: 2015


Sleep and Memory

Sleep and Memory Study

  • Depressed participants needed
  • Males and females over the age of 18
  • No history of head injury causing unconsciousness
  • Able to spend 2 to 4 nights in the lab and keep a fixed sleep schedule
  • Willing to complete interview, questionnaires, and computer tasks
  • Monetary compensation of $75 per lab night

Contact:
Adrienne McHenry
248-719-3887
amchenry@umich.edu


Major Depression & Type 2 Diabetes

The purpose of the study is to examine the relationship between brain structure and depression in adults aged 30 or older with Diabetes. This relationship is determined using MRI technology. We are looking for people with depression, Type 2 diabetes or people with both illnesses. Subjects may not be on anti-depressants.

Contact:
Monya Meinel, CCRC
312-996-6201
mmeinel@psych.uic.edu

Deadline: June 2014


Depression Research Study

Feeling overwhelmed? sad? depressed? You may be suffering from depression.
Doctors at the University of California Los Angeles are researching a new technology to predict antidepressant effectiveness. Qualifying participants, ages 18-75, will receive antidepressants, study-related exams, tests and clinical consultations - at no cost. Also, monetary compensation may be provided. We conduct numerous studies on depression and enrollment is ongoing.

Contact:
Lab of Brain, Behavior, and Pharmacology
310-825-3351
rohitm@brain.ucla.edu
http://www.brain.ucla.edu/

Deadline: Open


Depression Research Study (Southern California)

A Placebo-Controlled, Add-On (“Natural Supplement”) Study of MSI-195 (S-Adenosyl-L-Methionine, SAMe) For Patients With Major Depressive Disorder (MDD) Who Have Had An Inadequate Response to Current Antidepressant Therapy

The purpose of this study is to evaluate the safety and effectiveness of MSI-195 (SAMe) as an add-on treatment to an ongoing antidepressant medication. Qualified participants must be between 21 and 70 years of age and diagnosed with Depression. The duration of study participation is approximately two-to-three months, with up to six clinic visits and three telephone visits. Study-related care is provided at no cost to participants and compensation for travel is available. 

Pharmacology Research Institute (PRI) has been conducting research studies since 1975. Our offices are located in Orange County, Long Beach/Los Alamitos and Encino/San Fernando Valley. Please feel free to contact us or visit our website for more information. 

Contact:             
Mellissa M. Henry, R.N., M.S.N., N.P.
(888) 774-4673 or (714) 827-3667
mhenry@priresearch.com
www.priresearch.com

Deadline: Open


Deep brain stimulation for TRD

This study, conducted by Dr. Helen Mayberg, is looking a deep brain stimulation for the treatment of patients with treatment resistant depression. We are currently recruiting patients with bipolar type II depression and unipolar depression. For more information please contact us or visit our clinical trials website at: http://clinicaltrials.gov/ct2/show/NCT00367003?term=deep+brain+stimulation+for+depression&rank=6

Contact:
Megan Filkowski
dbs@emory.edu
(404)727-9228
http://clinicaltrials.gov

Deadline: Open