Research Studies: Bipolar Disorder
DBSA does not endorse nor recommend any particular research study. Patients should discuss all options with their health care providers and family members before beginning any study.
Many people think that participating in a research study means they will get better treatment for their illness. While this may be true, it's important to remember that a research study is conducted for research purposes—it does not ensure better or safer treatment.
Taking part in a study does not guarantee individual benefits to the participant in the form of newer or safer treatment. The contribution made participating in a research study is to science first and to the patient second.
DBSA, its advisors, and consultants do not endorse or recommend the use of any specific treatment or medication. For advice about specific treatment or medication, patients should consult their physicians and/or mental health professionals.
MoodSwings: An Online Self-Help Program for Bipolar Disorder
We are recruiting people who:
You are invited to participate in this research study to evaluate the MoodSwings online self-help program for bipolar disorder. We are interested in understanding how intensive the MoodSwings program needs to be to improve well-being in people with bipolar disorder, so we have 3 levels of access for participants involved in this study:
If you are eligible to participate in this study, you will be randomly assigned to one of these groups for 12 months. You will be asked to complete both online and telephone assessments at quarterly intervals across the 12 month study period.
There is a 1/3 chance that participants will be randomly assigned to a discussion board only group. While this is considered a control group, we do expect a modest benefit. All participants will have access to their allocated group for 12 months.
For more information, please visit:
Deadline for Enrollment: Ongoing
Pharmacokinetics of Lamotrigine in Pregnant and Postpartum Women with Bipolar Disorder (Chicago, IL)
Background: Lamictal (lamotrigine) is FDA approved and commonly used to treat Bipolar Disorder. Because Bipolar Disorder frequently affects women during their reproductive years, it is important for us to understand how the dose of Lamictal should be modified for women who are pregnant. By participating in this study, you can help optimize the quality of care for women with Bipolar Disorder.
Goal: To understand the need for changes in dosage level of Lamictal for pregnant women with a history of Bipolar Disorder
Eligibility: Women ages 18-45; Diagnosis of Bipolar Disorder; Planning to become pregnant, or in the first or second trimester of pregnancy; Taking daily dose of Lamictal (lamotrigine) for mood symptom management What you will do: At your initial visit, you will complete a full psychiatric evaluation with Dr. Clark at no cost to you. At each subsequent visit, you will stay overnight in the clinical research unit and complete assessments to monitor your mood, as well as blood draws to monitor your lamotrigine levels.
Compensation: Reimbursement for on-site parking or public transportation; Financial compensation between $75-125 for every study visit you complete; Medical consultation with Dr. Crystal Clark about the best treatment for you throughout pregnancy; Gifts for you and your baby; Careful monitoring of your mood symptoms throughout pregnancy at no cost to you Principal Investigator: Crystal T. Clark, MD, MSc
Deadline for Enrollment: 09/30/2015
A Clinical Trial of Mobile Telephone based Assessment and Intervention for Persons with Bipolar Disorder or Schizophrenia (La Jolla (San Diego), CA)
The purpose of this study is to evaluate the effectiveness of a mobile real-time cognitive behavioral intervention for serious mental illness (SMI) and to identify the facilitators, barriers, and costs of implementation. We would like to determine whether the addition of a mobile phone monitoring software program to a brief behavioral intervention for bipolar disorder or schizophrenia improves symptoms arising from the disorders. We aim to address symptoms, improve socialization, medication adherence, and relapse prevention.
Participants cannot receive any cognitive behavior therapy while in the study. There are three different groups. One is treatment as usual, one is active control, and one is treatment. There is an equal change of being randomized in each group.
Deadline for Enrollment: 05/31/2017
NIH Research Studies: Bipolar Disorder & Severe Irritability Symptoms (Bethesda, Maryland)
How do the brain and the symptoms change as children grow up?
Participants must have a bipolar diagnosis, or have symptoms of severe irritability. Irritability symptoms include: difficulty handling frustration (severe temper tantrums and rages) and "hyper" behavior (distractible, hyperactive, trouble sleeping).
Call for more information and eligibility criteria.
Deadline for Enrollment: Ongoing
The Experience of Women with Bipolar Disorder During Pregnancy: An Exploratory Study
We are recruiting women who:
You may qualify for a research study that could help researchers at the University of North Carolina-Chapel Hill Nursing School better understand the experience of pregnancy for women with bipolar disorder. If you qualify, this research project involves a 1-2 hour telephone interview where we will ask you about your most recent pregnancy experience and a short online questionnaire about your emotions. If you would like to participate in this study, please complete this brief online screening tool: http://bpdpregnancy.com, or e-mail email@example.com to complete it over the phone. Compensation for this study is a $15 gift card to Target or Wal-Mart.
Deadline for Enrollment: 5/31/14
Bipolar I Study: Depressed Episode
The purpose of the study is to evaluate the effectiveness and safety of the study medication in individuals with depressive symptoms, diagnosed with Bipolar I Disorder. The study medication will be used in addition to ongoing treatment with certain mood stabilizers and/or atypical antipsychotics. Participants need to be between 18 to 75 years of age, in generally good physical health and currently taking medication for bipolar disorder. Participation in the study will be from 8 to 12 weeks overall. Participants will receive study medication for a maximum of 6 weeks. Participants will receive compensation for their time and travel. All study related procedures and medications are provided at no cost.
Antidepressants and typical antipsychotics are prohibited during the study. Participants may not initiate cognitive or behavioral therapy, or psychotherapy during the study. Some participants will be randomly assigned to the placebo group. There is a one in three chance of being assigned to the placebo group during the dosing period (6weeks).
Deadline for Enrollment: December 2014
Structural and Functional Brain Aging in Bipolar Disorder (San Diego, CA)
We are interested in learning more about how the brain changes with age in those diagnosed with bipolar disorder. The study will involve adults of all ages with bipolar disorder and also those without a psychiatric diagnosis.
We are looking for individuals who are:
Deadline for Enrollment: 08/01/2014
Sequential Multiple Assignment Randomized Treatment (SMART) for Bipolar Disorder (Cleveland, OH)
If you are 18 years of age or older, have been diagnosed with Bipolar Disorder, are currently experiencing symptoms, and live in the Cleveland, OH area, you may be eligible to participate in a research study being conducted by the Mood Disorders Program at University Hospitals Case Medical Center. This study lasts up to 26 weeks and visits are every week or once a month, depening on where you are at in the study. Participants would be taken off of non-study medications.
Deadline for Enrollment: 06/30/2014
Stability - Bipolar I Depression Study (Skokie, IL & Chicago, IL)
Are you currently being treated for Bipolar Disorder and doing well?
We are looking for participants, with Bipolar Disorder who are stable to participate in our clinical research study. You must be currently taking medication for Bipolar I disorder to participate. Most medication combinations are acceptable.
Participants will be randomly assigned to 1 of 3 treatment groups or a placebo group - to receive remelteon (study medication) throughout the trial.
The purpose of the study is to if the study medication will keep participants stable, for longer periods.
*14 office visits over 9 months ($25 per visit paid)
Please call us today to further discuss the study design and inclusion criteria.
Deadline for Enrollment: 01/05/2015
Bipolar I Depression (Skokie, IL & Chicago, IL.)
Are you taking medication for BP I disorder and still currently depressed?
We are looking for participants who are currently being treated with lithium, a mood stabilizer, or an atypical anti-psychotic but still experiencing symptoms of depressions.
Participants will be allowed to remain on their current medication and will be randomly assigned to 1 of 3 treatment groups or a placebo group. The study will assess the efficacy of ramelteon (currently approved to treat insomnia) as an add-on therapy in the treatment if Bipolar I Disorder.
9 office visits over 9 weeks ($25 per visit paid)
All study related procedures, including physical examinations proved at no cost. 25% chance that subjects will receive a placebo as their add on medication.
Deadline for Enrollment: 01/05/2015
Bipolar Relapse Prevention - NIMH Study (Rush University Research Study conducted in Skokie, IL & Chicago, IL.)
The Bipolar relapse prevention study is a 17 visit, 62-week trial where subjects 18-65 who are currently depressed will be treated with the mood stabalizer lithium plus the antidepressant fluoxetine. This study begins with 12 weeks of treatment with fluoxetine plus lithium for mood symptoms. Subjects who respond (remission of symptoms) to the treatment will continue to receive lithium but will be randomly selected to continue receiving fluoxetine or switched to placebo. All Participants will recieve active medication through their participation in the study.
During the first 12-weeks of the study all subjects will be treated with fluoxetine and lithium. Subjects that are stable at the end of 12-weeks, will continue to receive lithium but will be radomized to receive fluoxetine or placebo (50/50 chance).
Deadline for Enrollment: 01/01/2015
Bipolar Disorder and Insulin-Resistant (Cleveland, OH)
PURPOSE: Patients with bipolar disorder have higher rates of insulin resistance than the general population. Currently, physicians do not know whether treating insulin resistance in people with bipolar disorder will lead to a decrease in depressive symptoms. The purpose of this study is to test whether pioglitazone, a medication that improves the efficiency of how the body uses blood sugar, is able to reduce depression severity.
ELIGIBILITY: Participants must be ages 18 to 75 with Bipolar Disorder (I, II, NOS); currently receiving treatment with an anti-manic drug or willing to receive treatment with an anti-manic drug. The following are considered anti-manic drugs: lithium, divalproex, carbamazepine, lamotrigine, olanzapine, quetiapine, risperidone, aripiprazole, asenapine, or ziprasidone. Participants cannot have a history of bladder cancer or heart failure. Participants cannot be diagnosed with dementia or taking insulin or rosiglitazone.
Deadline for Enrollment: 08/01/2014
Bipolar Depression and Biological Rhythms (Chicago, Illinois)
Have you ever felt that your timing was off or that you were simply out of synch when depressed? Then you might want to participate in this study!
We are conducting a Northwestern University-funded study of biological rhythms in bipolar depression. By examining certain hormone (melatonin) and rest-activity rhythms, this study will clarify whether there is a timing disturbance in these rhythms during depression and suggest novel antidepressant strategies. This is not a clinical study: you will be able to continue your current treatment without change.
You may qualify if:
This study involves the following procedures:
Deadline for Enrollment: September 2014
Developing Brain Function in Adolescent (Chicago, IL)
Developing Brain Function in Adolescent Bipolar Disorder
This study focuses on the developmental changes in cognitive and affective neural circuitry functioning in adolescents with Pediatric Bipolar Disorder (PBD) over a three-year period. We will characterize the course of illness and associated neurocognitive function in patients with PBD as well as determine the association between brain function and behavior.
During the study, participants will complete a baseline diagnostic interview, clinical assessments, neurocognitive and neuropsychological tests, and a functional MRI brain scan. Participants will also have the option to draw blood for pharmacogenetic analyses. Testing will be repeated once a year for three years after the baseline visit, four visits total.
Deadline for Enrollment: Ongoing
Bipolar Disorder Studies (Cincinnati, OH)
We are seeking participants who have experienced mood swings, periods of elation, excessive excitement, irritability, high energy, racing thoughts, poor sleep, poor judgment, and/or periods of depression. We have a large range of studies for adults, adolescents and children.
In addition, we are looking for children who are depressed or children who have a parent with bipolar disorder. We also have studies for adolescents with bipolar disorder who use substances.
Please visit our website to see a full listing of what we offer or contact Michelle or Jennifer below to see if you may be eligible for a study. http://www.psychiatry.uc.edu/ click on the clinical trials link on the left or participate in research at the bottom of the page.
Jennifer Vaden - Children
Deadline for Enrollment: January 1, 2015
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