Research Studies: Bipolar Disorder
DBSA does not endorse nor recommend any particular research study. Patients should discuss all options with their health care providers and family members before beginning any study.
Many people think that participating in a research study means they will get better treatment for their illness. While this may be true, it's important to remember that a research study is conducted for research purposes—it does not ensure better or safer treatment.
Taking part in a study does not guarantee individual benefits to the participant in the form of newer or safer treatment. The contribution made participating in a research study is to science first and to the patient second.
DBSA, its advisors, and consultants do not endorse or recommend the use of any specific treatment or medication. For advice about specific treatment or medication, patients should consult their physicians and/or mental health professionals.
Sequential Multiple Assignment Randomized Treatment (SMART) for Bipolar Disorder (Cleveland, OH)
If you are 18 years of age or older, have been diagnosed with Bipolar Disorder, are currently experiencing symptoms, and live in the Cleveland, OH area, you may be eligible to participate in a research study being conducted by the Mood Disorders Program at University Hospitals Case Medical Center. This study lasts up to 26 weeks and visits are every week or once a month, depening on where you are at in the study. Participants would be taken off of non-study medications.
Deadline for Enrollment: 06/30/2014
Stability - Bipolar I Depression Study (Skokie, IL & Chicago, IL)
Are you currently being treated for Bipolar Disorder and doing well?
We are looking for participants, with Bipolar Disorder who are stable to participate in our clinical research study. You must be currently taking medication for Bipolar I disorder to participate. Most medication combinations are acceptable.
Participants will be randomly assigned to 1 of 3 treatment groups or a placebo group - to receive remelteon (study medication) throughout the trial.
The purpose of the study is to if the study medication will keep participants stable, for longer periods.
*14 office visits over 9 months ($25 per visit paid)
Please call us today to further discuss the study design and inclusion criteria.
Deadline for Enrollment: 01/05/2015
Bipolar I Depression (Skokie, IL & Chicago, IL.)
Are you taking medication for BP I disorder and still currently depressed?
We are looking for participants who are currently being treated with lithium, a mood stabilizer, or an atypical anti-psychotic but still experiencing symptoms of depressions.
Participants will be allowed to remain on their current medication and will be randomly assigned to 1 of 3 treatment groups or a placebo group. The study will assess the efficacy of ramelteon (currently approved to treat insomnia) as an add-on therapy in the treatment if Bipolar I Disorder.
9 office visits over 9 weeks ($25 per visit paid)
All study related procedures, including physical examinations proved at no cost. 25% chance that subjects will receive a placebo as their add on medication.
Deadline for Enrollment: 01/05/2015
Bipolar Relapse Prevention - NIMH Study (Rush University Research Study conducted in Skokie, IL & Chicago, IL.)
The Bipolar relapse prevention study is a 17 visit, 62-week trial where subjects 18-65 who are currently depressed will be treated with the mood stabalizer lithium plus the antidepressant fluoxetine. This study begins with 12 weeks of treatment with fluoxetine plus lithium for mood symptoms. Subjects who respond (remission of symptoms) to the treatment will continue to receive lithium but will be randomly selected to continue receiving fluoxetine or switched to placebo. All Participants will recieve active medication through their participation in the study.
During the first 12-weeks of the study all subjects will be treated with fluoxetine and lithium. Subjects that are stable at the end of 12-weeks, will continue to receive lithium but will be radomized to receive fluoxetine or placebo (50/50 chance).
Deadline for Enrollment: 01/01/2015
Translational Cellular Models for Mood Disorders (Baltimore, MD)
This research is being done to study cells from participants with bipolar disorder (BP) and major depressive disorder (MDD). These severe mood disorders are diseases of the brain, but for understandable reasons, we are unable to obtain brain tissue samples from subjects suffering from these illnesses. As an alternative, we would like to study nerve cells from the nasal cavity (inside the nose), along with skin cells and white blood cells to determine whether there are important differences in these cells from subjects with mood disorders compared with healthy controls. If successful, this study may show that these easily accessible tissues can provide a valuable "window" into the brain and may reveal differences in specific genes and proteins that are associated with bipolar disorder and/or major depression.
This research study will last about 3-4 hours and can usually take place in one visit. It will consist of a clinical interview, a nasal procedure, a skin sample, and a blood sample. Participants will be paid $150 for the nasal procedure, $75 for the skin sample, $25 for the blood draw, and $25 for the clinical interview, in the form of a check that will be mailed to them within 4 weeks of the end of their participation. They will also be given a meal ticket in the amount of $6 to use at the cafeteria in Johns Hopkins Hospital and a parking voucher, if needed.
If participants agree to be in the study, we ask that they MUST BE OFF OF NON-STEROIDAL ANTI-INFLAMMATORY DRUG'S 10 DAYS PRIOR TO YOUR RESEARCH APPOINTMENT. Some common NSAID's include Ibuprofen (Advil, Motrin), Aleve (Naproxen), Bayer (Aspirin), Excedrin.
Deadline for Enrollment: 12/31/2013
Bipolar Depression and Inflammation (Maywood, IL)
You may be eligible to participate if:
Qualified participants will receive psychiatric medication for a maximum of eight visits over a period of 10 weeks. Participants will be compensated up to $360 for their time and travel. Participants would not be able to receive any other antidepressant treatment during the course of the study.
Deadline for Enrollment: 12/31/2013
Bipolar Disorder and Insulin-Resistant (Cleveland, OH)
PURPOSE: Patients with bipolar disorder have higher rates of insulin resistance than the general population. Currently, physicians do not know whether treating insulin resistance in people with bipolar disorder will lead to a decrease in depressive symptoms. The purpose of this study is to test whether pioglitazone, a medication that improves the efficiency of how the body uses blood sugar, is able to reduce depression severity.
ELIGIBILITY: Participants must be ages 18 to 75 with Bipolar Disorder (I, II, NOS); currently receiving treatment with an anti-manic drug or willing to receive treatment with an anti-manic drug. The following are considered anti-manic drugs: lithium, divalproex, carbamazepine, lamotrigine, olanzapine, quetiapine, risperidone, aripiprazole, asenapine, or ziprasidone. Participants cannot have a history of bladder cancer or heart failure. Participants cannot be diagnosed with dementia or taking insulin or rosiglitazone.
Deadline for Enrollment: 08/01/2014
Bipolar Depression and Biological Rhythms (Chicago, Illinois)
Have you ever felt that your timing was off or that you were simply out of synch when depressed? Then you might want to participate in this study!
We are conducting a Northwestern University-funded study of biological rhythms in bipolar depression. By examining certain hormone (melatonin) and rest-activity rhythms, this study will clarify whether there is a timing disturbance in these rhythms during depression and suggest novel antidepressant strategies. This is not a clinical study: you will be able to continue your current treatment without change.
You may qualify if:
This study involves the following procedures:
Deadline for Enrollment: September 2013
Longitudinal Study of Bipolar Disorder (Michigan)
Age: Minimum age of 18
Bipolar and Healthy Control Research Participants Needed. The Bipolar Research Group at the University of Michigan Department of Psychiatry and Depression Center, is seeking individuals of at least 18 years of age with a diagnosis of bipolar disorder without a history of schizophrenia. Investigators also seek healthy controls with no diagnosis. The purpose of the study is to identify potential illness patterns in bipolar disorder. This will be done through the analysis of genetic information and continued observation for ten years. Study participation involves an initial visit consisting of a structured interview, cognitive testing, questionnaires, and a blood draw for genetics and biomarkers, after which interviews and questionnaires will be performed at various time intervals. Participants are compensated $100 for the initial visit and up to $150 for each annual visit. This study has received approval from IRBMED: HUM00000606
Deadline for Enrollment:December 31, 2013
Decision-Making in Bipolar Disorder (Emory University Atlanta, GA)
We are conducting a study of how Bipolar Disorder affects how people make decisions and how treatment may change that decision-making.
To participate, you must be:
Participants will undergo a psychiatric assessment, questionnaires and tests about decision-making. They will also receive treatment with one of the following FDA-approved medications for the treatment of bipolar disorder: lithium, valproate or lamotrigine.
Patients would not be restricted from receiving non-psychotropic treatments; however, they would be restricted from receiving stimulants, antipsychotics and specific antidepressant medications while participating in the study.
Deadline for Enrollment: May 2013
Capacity to Consent to Research... (San Diego, CA)
We are trying to find out if symptoms of Bipolar Disorder affect people's ability make decisions.
The study lasts approximately 6 months and includes 5 study visits. The visits last 2 to 3 hours and participants are compensated $30 per visit.
We will ask participants questions about current and past symptoms. Participants will complete tests that measure their ability to make decisions, as well as, tests of memory, concentration, and thinking abilities.
We are looking for individuals who are at least 18 yrs old and have a diagnosis of Bipolar Disorder.
Deadline for Enrollment: 12/31/2013
Developing Brain Function in Adolescent (Chicago, IL)
Developing Brain Function in Adolescent Bipolar Disorder
This study focuses on the developmental changes in cognitive and affective neural circuitry functioning in adolescents with Pediatric Bipolar Disorder (PBD) over a three-year period. We will characterize the course of illness and associated neurocognitive function in patients with PBD as well as determine the association between brain function and behavior.
During the study, participants will complete a baseline diagnostic interview, clinical assessments, neurocognitive and neuropsychological tests, and a functional MRI brain scan. Participants will also have the option to draw blood for pharmacogenetic analyses. Testing will be repeated once a year for three years after the baseline visit, four visits total.
Deadline for Enrollment: Ongoing
Memory Problems in Bipolar Disorder (Massachusetts General Hospital-Boston, MA)
Do you have bipolar disorder and are currently stable?
Do you have difficulty remembering things?
If so, you may be eligible to participate in a research study at Massachusetts General Hospital's Bipolar Research Program examining the effect of a medication treatment on memory functioning in patients with bipolar disorder.
Participation includes 16 weeks of treatment with galantamine or placebo (contains no active medication), two sessions of neuropsychological testing, and a total of six research study visits. Subjects will be compensated for participation.
Contact: Aleena at the Massachusetts General Hospital's Bipolar Research Program at 1-866-99-MOODS (1-866-996-6637) for more information.
Deadline for Enrollment: June 2013
Bipolar Disorder Studies (Cincinnati, OH)
We are seeking participants who have experienced mood swings, periods of elation, excessive excitement, irritability, high energy, racing thoughts, poor sleep, poor judgment, and/or periods of depression. We have a large range of studies for adults, adolescents and children.
In addition, we are looking for children who are depressed or children who have a parent with bipolar disorder. We also have studies for adolescents with bipolar disorder who use substances.
Please visit our website to see a full listing of what we offer or contact Michelle or Jennifer below to see if you may be eligible for a study. http://www.psychiatry.uc.edu/ click on the clinical trials link on the left or participate in research at the bottom of the page.
Jennifer Vaden - Children
Deadline for Enrollment: January 1, 2015
Bipolar CHOICE Study at Cornell Medical Center in New York City
This federally funded study is being conducted at ten different medical centers across the United States in individuals 18-68 years of age, diagnosed with Bipolar Disorder I or II and having at least mild current symptoms. The study will test whether lithium or quetiapine (Seroquel) in combination with other medications usually prescribed for bipolar disorder is more effective. Participants must be willing to be randomly selected to take lithium or Seroquel. This study lasts up to 6 months. Visits are once every 2 weeks for the first 2 months and then monthly thereafter. Study participants will receive study-related treatment, research medication and evaluation at no cost. Subjects receive $50 per visit. For more information please call the Affective Disorders Research Clinic at Weill Cornell Medical Center.
Deadline for Enrollment: November 2013
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