Medication Information Sheet

Medications Approved by the Food and Drug Administration (FDA) for Depression

Please note that the list below may not include all possible side effects or all possible interactions. You should thoroughly discuss all medication choices with your doctor. DBSA does not endorse or recommend the use of any specific treatment or medication for mood disorders. Consult your doctor for more information about specific treatments or medications.

Medication class Medication Brand names How it works in the brain Some possible side effects May interact with

Selective serotonin  reuptake
inhibitors
(SSRI)

Citalopram
Escitalopram
Fluvoxamine
Paroxetine
Fluoxetine
Sertraline

Celexa®
Lexapro®
Luvox®
Paxil®
Prozac®
Zoloft®

 

+serotonin

Nausea
Insomnia
Sleepiness
Agitation
Sexual dysfunction
Withdrawal symptoms if stopped
abruptly (except fluoxetine)

Call your doctor immediately if you start to feel suicidal.

MAOIs
Tricyclic anti-
depressants
Alcohol
Tranquilizers
Blood-thinning medications
Anti-
convulsants
Heart
medications

Norepinephrine and 
dopamine reuptake
inhibitors
(NDRI)

 

Bupropion

Wellbutrin®
Wellbutrin- SR®

 

+norepin-
ephrine
+dopamine

 

Agitation
Insomnia
Anxiety
Dry mouth
Headache
Seizures 
are a
danger when
there are specific risk
factors
such as previous seizures, heart trauma, eating disorders, or

MAOls
Tricyclic anti-
depressants
Tranquilizers
Phenobarbital
Steroid medications
Anticonvulsants
Alcohol
Insulin
Diabetes medications

Serotonin antagonist
and reuptake inhibitor  
(SARI)

Trazodone
Nefazodone

Desyrel®
Serzone®

 

+serotonin

Nausea
Dizziness
Sleepiness
Dry mouth
Constipation
Weight gain
Possible serious liver damage
(nefazodone only) if you experience yellowing of the skin, nausea or abdominal pain, contact your doctor or hospital
immediately.

Tranquilizers
BuSpar
MAOIs
Digoxin 
(Lanoxin)
Sleep 
medications

 

Serotonin and norepin-
ephrine reuptake inhibitor (SNRI)

Venlafaxine
Duloxetine

 

Effexor®
Effexor XR®
Cymbalta®

 

+serotonin
+norepin-
ephrine

 

Anxiety
Nausea
Dizziness
Sleepiness
Sexual
dysfunction
Withdrawal
symptoms when stopped abruptly

MAOIs 
Ulcer medications or stomach acid reducers such 
as Tagamet

Noradnergic and specific serotonergic antidepressant (NaSSA)

Mirtazapine

Remeron®

+serotonin
+norepin-
ephrine

 

Sleepiness
Increased appetite
Weight gain
Dizziness
Dry mouth
Constipation

MAOIs 
Alcohol Tranquilizers

Tricyclic
(TCA), Tetracyclic

Clomipramine
Amitriptyline
Desipramine
Nortriptyline
Trimipramine
Imipramine
Protriptyline
Amoxapine
Maprotiline

 

Anafranil®
Elavil®
Norpramin®
Pamelor®
Surmontil®
Tofranil®
Vivactil®
Asendin®
Ludiomil®

 

+serotonin
+norepin-
ephrine
(depending
on 
medication)

 

Sleepiness
Nervousness
Dizziness
Dry mouth
Constipation
Urinary retention
Increased appetite
Weight gain
Low blood pressure
Sexual dysfunction
May be toxic if levels in blood
get too high

Alcohol 
Sleep 
medications Antihistamines Cold medicines Pain medications Heart medications Tranquilizers 
Birth control or hormone pills Anticonvulsants Drugs that control spasms

Monoamine oxidase inhibitor
(MAOI)

Phenelzine
Tranylcypromine
Isocarboxazid

 

Nardil®
Parnate®
Marplan®

+serotonin
+norepin-
ephrine
+dopamine

Dizziness
Dry mouth
Urinary retention
Sleep problems
Low blood pressure
Weight gain
Sexual dysfunction
Dangerously high blood
pressure if taken with the

Fatal interaction with some prescribed and over-thecounter medications (such as cold medications, and Demerol) Interaction with some foods (you’ll need to be on a strict diet low in a chemical called tyramine)

Medications Approved by the Food and Drug Administration (FDA) for Bipolar Disorder

Please note that the list below may not include all possible side effects or all possible interactions. You should thoroughly discuss all medication choices with your doctor. DBSA does not endorse or recommend the use of any specific treatment or medication for mood disorders. Consult your doctor for more information about specific treatments or medications.

Medication Brand names How it works in the brain Some possible side effects May interact with

Lithium carbonate

Lithionate® Lithotabs® Lithobid® Eskalith®

+serotonin +brain and nerve cell activity

Shaking
Nausea
Feeling “dulled”
Fatigue
Frequent urination Increased thirst Dehydration
Diarrhea
Dry mouth
Weight gain
Lowered thyroid activity Kidney trouble
May be toxic if blood levels get too high
Avoid excessive sweating or becoming dehydrated, which can cause your lithium levels to get too high.

Antidepressants Anti-inflammatory medications (such as ibuprofen)
Caffeine
Calcium-blocking medications
Carbamazepine (Tegretol) Diuretics
High blood pressure medications Iodine-containing preparations
Major tranquilizers Metronidazole (Flagyl) Phenytoin (Dilantin)

Divalproex sodium

Depakote®

+GABA (gamma- aminobutyric acid)

Nausea
Shaking
Weight gain
Decrease in blood platelets
Rash
Pancreatitis
Liver dysfunction (rare)
Polycystic Ovary Syndrome (rare)

Aspirin
Tegretol
Lamictal
Blood thinners such as Coumadin
Barbiturates such as phenobarbital and Seconal Cyclosporine (Sandimmune, Neoral)

Olanzapine Zyprexa®

- dopamine +serotonin

Drowsiness
Dry mouth
Shaking
Increased appetite Weight gain

Tranquilizers
Sleep medication

Fluoxetine + Olanzapine

Symbyax®

+serotonin +norepinephrine -dopamine

Dizziness
Drowsiness
Dehydration
Headache
Nausea
Sweating

MAOI antidepressants Thioridazine
Pain relievers
Blood pressure or heart medications Anticonvulsants
Herbal remedies
Alcohol or sedatives

Lamotrigine Lamictal®

+NMDA (N-methyl D-aspartate)

Blurred vision Sleepiness
Headache
Nausea
Sensitivity to sunlight
*If rash occurs, contact your doctor immediately.

Depakote (Divalproex sodium)
Tegretol (Carbemazepine) Bactrim
Proloprim
Septra
Phenobarbital,phenytoin, primidone
Birth control pills

Risperidone Risperdal®

-dopamine +serotonin

Weight gain
Sedation
Increased saliva Stiffness
Shaking
Restlessness
Low blood pressure

Blood pressure medications Medications that slow the central nervous system, such as other antipsychotics or tranquilizers
Heart medications Medications for Parkinson’s disease

Quetiapine fumarate

Seroquel®

-dopamine +serotonin

Weight gain
Sedation
Dry mouth
Constipation
Stiffness
Shaking
Restlessness
Low blood pressure

Barbiturates
Antibiotic or antifungal medications
Tranquilizers
Ulcer medications such as Tagamet
Steroid medications
Alcohol

Ziprasidone Geodon®

-dopamine +serotonin +norepinephrine

Tiredness
Dizziness
Restlessness
Cough
Shaking
Nausea
Stiffness
Stomach upset
Insomnia
Rash
Tell your doctor if you have ever had heart problems. Contact your doctor or an emergency room immediately if you faint or feel a change in your heartbeat.

Anti-arrhythmic heart medications such as dofetilide, solatol or quinidine
Blood pressure medications MAOI antidepressants Carbamazepine (Tegretol) Oxcarbazepine
Barbiturates
Levodopa
Ketoconazole
Thioridazine (Mellaril) Mesoridazine Chlorpromazine
Droperidol
Pimozide
Sparfloxacin, gatifloxacin, moxifloxacin
Halofantrine, mefloquine, pentamidine
Arsenic trioxide Levomethadyl acetate Dolasetron mesylate Probucol
Tacrolimus

Aripiprazole Abilify®

-dopamine +serotonin

Insomnia
Nausea
Restlessness
Tiredness

Paroxetine (Paxil)
Fluoxetine (Prozac) Paroxetine (Paxil) Carbamazeine (Tegretol)

Carbemazepine 

Tegretol® Tegretol-XR® Epitol® Carbitrol® Equetro®

+GABA, serotonin and others

Blurred vision
Dizziness
Dry mouth
Drowsiness
Nausea
Decreased white blood cell count
Shaking
*If rash occurs, contact your doctor immediately.

Birth control pills (can make them ineffective)
Lithium
Lamictal (Lamotrigine) Depakote (Divalproex sodium) Anticonvulsants/Antiseizure medications
Tricyclic antidepressants Antibiotics
Tranquilizers
Cancer medications

Anticonvulsants that may be Prescribed for Bipolar Disorder

Please note that the list below may not include all possible side effects or all possible interactions. You should thoroughly discuss all medication choices with your doctor. DBSA does not endorse or recommend the use of any specific treatment or medication for mood disorders. Consult your doctor for more information about specific treatments or medications.

Medication Brand names How it works in the brain Some possible side effects May interact with
Oxcarbazepine Trileptal®

+GABA, serotonin
and others

Blurred vision Dizziness
Dry mouth
Sedation
Upset stomach Drowsiness Unsteadiness

Birth control pills (can make them ineffective)  
Lithium
Lamictal (Lamotrigine) Depakote (Divalproex sodium) Anticonvulsants/Antiseizure medications
Tricyclic antidepressants Antibiotics
Tranquilizers
Cancer medications Felodipine (Plendil)
Verapamil (Covera, Calan, Isoptil, Verelan)

Gabapentin Neurontin® +GABA

Blurred vision Dizziness
Fatigue
Nausea

Antacids
Birth control pills

Topiramate Topamax® +GABA

Drowsiness Memory problems Feeling “dulled” Weight loss
Kidney stones
*If you have changes in vision, eye pain or redness, or increased eye pressure, contact your doctor immediately.

Other anticonvulsants Acetazolamide (Diamox), Dichlorophenamide (Daranide)
Digoxin (Lanoxin)
Birth control pills
Alcohol
Sleep medications Antihistamines
Tobacco

Zonisamide Zonegran® +GABA

Possible allergic reaction Drowsiness
Upset stomach Headache
Irritability
Inability to sweat (contact your doctor if you get overheated or feverish)

Other anticonvulsants Antidepressants (SSRIs) Antifungals/Antibiotics Antihistamines
Birth control pills
Heart medications
Alcohol

Antipsychotics that may be Prescribed for Bipolar Disorder

Please note that the list below may not include all possible side effects or all possible interactions. You should thoroughly discuss all medication choices with your doctor. DBSA does not endorse or recommend the use of any specific treatment or medication for mood disorders. Consult your doctor for more information about specific treatments or medications.

Medication Brand names How it works in the brain Some possible side effects May interact with
Trifluoperazine Stelazine® -dopamine

Constipation
Dry mouth
Insomnia
Headache
Rigidity
Restlessness Shakiness

 

Alcohol
Barbiturates
Pain medication Antiseizure drugs such as Dilantin
Atropine (Donnatal)
Blood thinners such as Coumadin
Guanethidine (Ismelin)
Lithium
Propanolol
Thiazide diuretics

Haloperidol Haldol® -dopamine

Constipation
Rigidity
Restlessness Shakiness

Dilantin
Tegretol
Bentyl
Blood-thinners such as Coumadin
Antidepressants such as Elavil, Tofranil, Prozac 
and Effexor
Epinephrine
Lithium
Methyldopa
Propanolol
Rifampin

Thioridazine Mellaril® -dopamine

Constipation
Nausea
Twitching
Rigidity
Visual problems
Dry mouth
Heart problems Contact your doctor or an emergency room immediately if you faint or feel a change in your heartbeat.

Alcohol
Pain medications Tranquilizers
Sleep medication Epinephrine
Phosphorus insecticides Pindolol
Propanolol and other heart medications
Antibiotics